These shoes are pretty great. I normally wear a 10.5 in Asics for running shoes and went with the 11s for these after trying on 43.5, 44, and 44.5 euro - interestingly the 10.5 in Asics is 44.5 Euro and the 11 La Sportiva was also 44.5, so their sizing is actually different as opposed to just "running small".
As far as performance, I am a big fan of the traction they provide. I did an off trail scramble (class 2/3) in the Sierras and felt very comfortable with their grip on sloped talus. Even with the fair amount of padding, I haven't experienced any additional ankle rolling tendencies. I also liked the rigidity underfoot for stepping on rocks and edges - obviously not as good as a full on hiking boot, but much better than a standard running shoe.