These shoes are very aggressive--downturned, asymmetrical toe, tight tight tight. I've heard 5.10s are great for durability--so far they seem tough. The rubber is amazing, sticks to everything.
For sizing, I went down a half size from my 12 street shoe. At first I tried a 10.5, but they were just too ridiculous. The 11.5s I have now are still tight and painful, and I'm still fighting through the blisters, but it will be worth it once they fully conform to my feet. They have already started to do so a bit. I have a friend who wears an 11.5 street shoe and wears 9 dragons, but I think he's crazy. I would suggest going with a half size below your street shoe if you have a relatively normal or narrow width foot. Try them on if you can--but remember these shoes aren't for walking around in, they are meant for climbing steep, technical faces.