How durable is the sole? I'm looking for a shoe I can do anything in. The skylite is my first choice, due to the less aggressive sole, but no where seems to have them in my size (~45). If I were to get these, would those heavy lugs get destroyed by doing stuff on anything but trails?

Oh, I also forgot to mention that I also occasionally play futsal on a basketball court and indoor soccer on turf wearing these. I also wear them for everyday use. They are pretty much the only shoe I wear for anything since I found them. The only other shoes I wear are my climbing shoes, which, not so coincidentally, are also La Sportivas.

I use these shoes for every surface there is. I road run, track run, trail run, and scramble in them, and even used them for climbing at the gym when I forgot my climbing shoes. I've worn them in snow and mud as well. The lugs take it all and ask for more. They are a little bit softer rubber which makes them more durable, but may decrease the overall wear life just a smidge. I would say even if you were to road run in them 5 days a week, they are going to last you at least 6 to 8 months. If you don't do that much road running they are going to last you much longer.