Has anyone ever tried these in running shoes? I'm not sure if there is enough room to accommodate the thicker insert. I'm current using the Dean Karnazes foot bed but thinking the Ed V's will give me more cushioning.

i did the same, slid them in my La Sportiva Raptors and WOW...what a different shoe...like it was tailored for my foot!

Absolutely! I was preparing for my first marathon in Nike Vomero 5's and was having terrible foot pain after my long runs. I went to my local running store and they recommended footbeds to support my feet. I realized that I already had Viesturs Sole Footbeds in my hiking boots so I pulled them out and put them into my Nike's and had a great run at the St George Marathon. I highly recommend them.

Bingo. I've ben using these in some Brooks trance running shoes for the past 3-4 years, Cushion and support are a tag team that's hard to beat with these. After you fit/mold them in the oven to fit your feet, fit them too your shoes by slipping them in and just wearing them around to see if you need to trim them up at all. Other piece of advice, fit the shoes you are going to put them in a little big, I wear an 11.5 street shoes and 12 running shoes, part of that is probably just sizing between different shoe brands, but make sure that your feet aren't cramped. After taking them on a 30k trail run with major downhills and having no heel slippage, I knew that this was the solution to my footwear woes, hope it works for you too.