Hey i wanna pick up a pair of these before i head out to moab and indian creek, but i am not sure of the sizing and there is nowhere around here that i can try them on.
The only 5.10 shoes i have right now are anasazis and they are 6.5s but they are very tight fitting.
Would the moccasyms fit all right if i went up a size to a 7.5?

If you haven't bought these bad boys yet. When I purchased these I had performance in mind. I wear a size 10,5 in street shoes for my Guide Tennies and i sized them down twice. The 8.5 Moccs I have are very comfortable and they WILL STRETCH!!! I do enjoy these for my seconds' and they are great!! Especially if your going to jam these into cracks as in Indian Creek. But it's all in preference and how much you want out of these shoes. If you want to be moderate I would size these one size down and if you r a madman like me size them down two times..hope this is helpful.

Like Thunder Horse said; these are leather uppers and will stretch about 1/2 a size. Where your Anasazis are synthetic and had a straight out of the box fit. Honestly I wouldn't size up at all, and depending on how tight your Anasazis are you might even want to size down to accommodate the stretch of the leather. More information about how your Anasazia fit and how you want these to fit would help us answer your question better.

It depends on your normal shoe size, which you didnt mention. If 6.5 is too tight I'd say 7.0 might be what you shooting for. Bear in mind these will stretch quite a bit (.5 -1 full size) but will match your foot perfectly once they do. Lucky Trails