Using as a day bag and as much needed carry-on capacity during multi-plane working trips. I'm using it as my day bag; Padding is excellant, plus plenty of room for computer support gear, and the all important extra change of clothes. This is about the largest bag you can carry on and still fit well in most overhead bins. Perhaps the biggest benefit is that it doesn't scream "Steal me, I have a laptop inside". Highly recommend.
I took mine to Kazakhstan on rotation into a uranium mine site. It easily swallowed the allowed 20 Kilos of cold weather clothing and tools. This trip involves 4 different aircraft and a 5 hour truck ride. Baggage handling is "how far can it be thrown". Never missed a beat, I'm buying another. The carry handle pocket saves the handle from snags during handling. I saw 2 destroyed handles during this trip alone.
As with any device, some compromises must be accepted. The quick inflation feature is well executed and is a pleasure to have. The outer covering is soft and bulletproof, yet does not breath well and causes some sweating. If you need portability and are space critical like I am, this is a great pillow. If a little sweat is unacceptable, use a bulkier traditional cotton setup. Hence, the compromise.
Also, it makes a great cushion for 2 portable hard drives, while I'm working overseas. I carry it in my computer bag while in-country, just tuck them in with the pillow deflated.