They work, but not sure they're worth the extra effort.
I bought these socks because I frequently get blisters in between my toes when I go for hikes with extended down-hill sections (amplified when carrying weight). They did accomplish this job, but they are a real pain to get on and off. Additionally, I think my toe length isn't right for these as there was a lot of extra room at the top of my pinky toe. They also seem to be a little more sensitive to the washing machine (washed on delicate cycle and they came out with little balls of wool all over them)