This is a great pack. The suspension systems is one of the best I have ever used, the pivot at the bottom really gives more freedom then any other similarly sized pack that I have ever used... you don't realize it until you put something else on and feel how stiff most hip belts make you feel. I have comfortably used the pack for everything from hauling my books around campus to weeklong backpacking trips. It cinches down nicely with smaller loads, but when packing for a week and carrying around 45 lbs I still had extra room had I needed.
Small annoyances are that:
it is basically one huge space, with just the brain on top for organizing smaller stuff, so you will probably want to invest in some stuff sacks to organize your stuff.
the ventilation system isn't the best in the world. It's not a trampoline style, but it's pretty good for mesh and foam core. (The day a company comes up with a trampoline style pack along with a pivoting hip belt will be a grand day indeed)
No bottoms access... I guess with a pack this size it is somewhat to be expected, but a zipper along the bottom so you can pull out your sleeping bag without emptying the pack would be nice.
Basically this is an extremely versatile pack that can comfortably handle just about anything, and doesn't restrict you like most packs.